Phosphoinositide 3-Kinase γ and p85/Phosphoinositide 3-Kinase in Platelets

Activation of Phosphoinositide 3-Kinase γ by Ras

domain-containing adaptor subunit, p85 , p85 , or p55 , Background: Type I phosphoinositide 3-kinases are rederived from three possible genes (or their splice varisponsible for the hormone-sensitive synthesis of the ants). Class IA can be activated directly by the associalipid messenger phosphatidylinositol(3,4,5)-trisphostion of the SH2 domains of their regulatory subunits phate. Type IA and I...

Phosphoinositide 3-kinase signalling pathways.

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3'-OH position of the inositol ring of inositol phospholipids, producing three lipid products: PtdIns(3)P, PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3). These lipids bind to the pleckstrin homology (PH) domains of proteins and control the activity and subcellular localisation of a diverse array of signal transduction molecules. Three major classes o...

Phosphoinositide 3-kinase activation and platelet function.

Age-independent synaptogenesis by phosphoinositide 3 kinase.

Synapses are specialized communication points between neurons, and their number is a major determinant of cognitive abilities. These dynamic structures undergo developmental- and activity-dependent changes. During brain aging and certain diseases, synapses are gradually lost, causing mental decline. It is, thus, critical to identify the molecular mechanisms controlling synapse number. We show h...

Regulation of Diacylglycerol Kinase by Phosphoinositide 3-Kinase Lipid Products*

Diacylglycerol kinase (DAGK ), like all type I DAGKs, has calcium regulatory motifs that act as negative regulators of enzyme activity and localization. Accordingly, DAGK is activated by phospholipase C-coupled receptors in a calcium-dependent manner. One of the first functions attributed to DAGK in lymphocytes was that of regulating interleukin 2-induced cell cycle entry. Interleukin-2 nonethe...